ORGLIST: reduction of lactone to lactol product..Is it DIBALH or NaBH4 or LAH????

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From: Suraya Zulkepli (kinrara_16$##$yahoo.com)
Date: Wed Jul 08 2009 - 22:35:22 EDT

Hello...

I just want to ask what are necessary reagents for
reduction of lactone to lactol product? Here,I'm attached the scheme
reaction what I want to do..

Is it DIBALH or NaBH4 or LAH???? Any good suggestion from you all??

Could I reduce with 20% solution DIBALH in hexane??Its because Malaysia could not get the pure DIBALH..(discontinued product) I knew..Mostly
researchers used DIBALH to get the lactol product.(from journals)

I
have tried with NaBH4 but I dont think I get the lactol..bUt LAH I
think the product will be diol..coz mostly journal said like that..

Hope anyone can reply me SOON!!..

Thank you SO MUCH.

      


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