Re: ORGLIST: removal of protective group in NŠ-Boc-Nš-Fmoc-L-ornithine

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From: Jose Olucha (joseolucha$##$gmail.com)
Date: Mon Dec 15 2008 - 21:50:39 EST


The companies you provided *DO* have the the Boc-Orn I need!

 I'll be calling them tomorrow...

Thanks for your help!

Jose

2008/12/15 Chapman, Robert D n/a <robert.chapman$##$navy.mil>

> Jose:
>
> I see, apparently mpbio.com named it wrong (or gives the wrong CAS number
> for the compound you want!), and even emolecules.com includes both
> synonyms, alpha and delta, for that CAS number:
> http://www.emolecules.com/cgi-bin/more?vid=535408
> So how about any of the sources at
> http://www.emolecules.com/cgi-bin/search?q=21887-64-9
> such as
> http://www.oakwoodchemical.com/search/Oaklookup.asp?mNumber=M03343
> or new Google hits
> http://ebiochemia.com/biochemia16_pdf/amino_acid_pdf/Ornithine.pdf
> http://pllabs.com/p_chem.php?cat=23&header=Amino+acid+Boc+derivatives
> http://www.orpegen.com/share/Catalog_Boc2006.pdf
>
> Sincerely,
>
> Robert D. Chapman, Ph.D.
> Chemistry Branch (Code 4L4200D)
> Naval Air Warfare Center
> China Lake, CA 93555-6106
>
>
>
> -----Original Message-----
> From: Jose Olucha [mailto:joseolucha$##$gmail.com]
> Sent: Monday, December 15, 2008 17:27
> To: Chapman, Robert D n/a
> Subject: Re: ORGLIST: removal of protective group in
> NŠ-Boc-Nš-Fmoc-L-ornithine
>
> Almost, but no such luck... Unfortunately, Sigma only sells the
> Boc-L-Ornithine with the Boc on side chain amine. I am looking for CAS #
> 21887-64-9.
>
> I will take a look at the list you provided, but so far my google-fu only
> found Synthetec <
> http://store.synthetech.com/customer/search.php?substring=boc-l-ornithine>
> provinding this ornithine derivative, in bulk (minimum purchase 50g, when I
> am looking for a couple of grams for right now).
>
> Thank you,
>
> Jose
>
>
>
> 2008/12/15 Chapman, Robert D n/a <robert.chapman$##$navy.mil>
>
>
> Jose:
>
> A variant of your phrase "NŠ-Boc-L-ornithine" input into a Google
> search for
> Nalpha "Boc-L-ornithine"
> gave 24 hits including the attractive one
> http://www.mpbio.com/index.php?cPath=492_501&page=62
> which contained a link to
>
> http://www.mpbio.com/product_info.php?cPath=492_501&products_id=152037&osCsid=tmv12pvo19tbrfjh5rluojm7e1
> Is that the right compound? That page gives its CAS Registry number,
> and then a Google search on that
> "13650-49-2"
> gives 26 more hits for your specific compound, including a list of
> vendors at
> http://www.emolecules.com/cgi-bin/search?q=13650-49-2
> which includes
>
> http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=B8126|SIGMA&N5=Product%20No.|BRAND_KEY&F=SPEC><
>
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=B8126%7CSIGMA&N5=Product%20No.%7CBRAND_KEY&F=SPEC
> >
> which has it available in 1-5 grams.
>
> Sincerely,
>
> Robert D. Chapman, Ph.D.
> Chemistry Branch (Code 4L4200D)
> Naval Air Warfare Center
> China Lake, CA 93555-6106
>
>
>
> -----Original Message-----
> From: everybody-bounces$##$orglist.net [mailto:
> everybody-bounces$##$orglist.net] On Behalf Of Jose Olucha
> Sent: Monday, December 15, 2008 14:09
> To: everybody$##$orglist.net
> Subject: ORGLIST: removal of protective group in
> NŠ-Boc-Nš-Fmoc-L-ornithine
>
> Hi,
>
> I am a biochemist with very little synthetic chemistry experience,
> so I apologize in advance for my possibly-ridiculously-obvious questions.
>
>
> I am derivatizing ornithine (non-proteogenic AA), and need
> NŠ-Boc-L-ornithine as a starting compound, which so far I've found not to be
> available commercially except in bulk (if you know otherwise, please tell me
> where I could purchase gram quantities!!).
>
> Can I purchase NŠ-Boc-Nš-Fmoc-L-ornithine and remove the Fmoc
> protective group (with 20% piperidine in DMF) without removing the Boc
> protective group (or vice-versa for that matter)?
>
> Thank you,
>
> Jose
>
>
>
>
>
>
>
>


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