ORGLIST: Molecular exclusion chromatography of low mw compounds

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From: Jarl Wikberg (jarl.wikberg$##$farmbio.uu.se)
Date: Mon May 26 2008 - 06:20:53 EDT


Dear all,

We have a separation problem for two steroid like compounds; one is mw 700
and another just above 800. We have tried everything for reversed phase,
normal phase and chiral chromatography and all different solvents but its
virtually impossible to separate them. Would anyone know have experience
with size exclusion chromatography of such small hydrophobic compounds?
Would it be feasible to separate them using e.g. cross-linked
styrenedivinylbenzenepolymer for HPLC or the alike?

All comments are appreciated!

 

Jarl Wikberg


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