Re: ORGLIST: synthesis of N oxalylglycine

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From: Khalid Mirza (khalidsmirza$##$
Date: Wed Dec 26 2007 - 18:58:21 EST

Here is general procedure for the synthesis of OxaIo Amino acids

Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate
analog N-oxaloglycine and its derivatives
C. Jane Cunliffe, Trevor J. Franklin, Neil J. Hales, and George B. Hill

On Dec 26, 2007 6:23 PM, robert bond <robertbondster$##$> wrote:

> Hi there
> I am kindly asking your help-as I am a Veterinarian in USA not a Chemist.
> I realise this question will be easy for you-however it is very important
> to me and I am praying you can help a beginner.
> I need to do research with the below compound-but as it is not
> commercially available-I need to synthesise it
> Q. What are the exact steps to make N Oxalyl Glycine Cas 5262-39-5 ??
> I see it is formed by the reaction of Glyoxylic Acid and Ammonia.
> These are both liquids-but N Oxalylglycine is a colourless solid.
> Do I just mix the 2 liquids together and heat them up?
> Will the resuling synthesis result in pure N Oxalyl glycine?
> How do I get it out of solution?
> Your help will be greatly appreciated
> Kind regards and Happy Holidays
> Robert
> robertbondster$##$

Khalid Mirza
Graduate Student
The Bradley Research Group
Department of Chemistry
Drexel University

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