Re: ORGLIST: Neutralizing TLC plates?

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From: JASON SMITH (jason.smith1$##$students.mq.edu.au)
Date: Tue Jun 05 2007 - 02:54:26 EDT

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Maybe in reply to: Ken Knott: "ORGLIST: Neutralizing TLC plates?"

Stability on silica can be checked by running a 2D TLC:

Using a square silica plate, spot the sample in one corner.

· Run the plate in one direction (all components of the sample will appear in a vertical line of spots).

· Turn the plate 90 degrees (your "line of spots" should be at the bottom) and run the plate again.

· If the sample is stable to silica, all spots will appear on the diagonal.

-Jason

Ken Knott wrote:
> I have a compound that I think may be degrading on TLC plates due to
> the mild acidity.
>
> I would appreciate advice on how to neutralize TLC plates prior to
> running them. I understand that this can be done with a 1% solution
> of TEA in your eluent prior to running the compound? Can anyone offer
> any suggestions or advice on doing this?
>
> Also, how might I make myself more certain that I am in fact
> witnessing degradation of my compound as a result of running it on the
> TLC?
>
> Thanks in advance!
>
> Ken
>
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You may try passivating the TLC plate with hexamethyl disilazane (HMDS)
via a vapor treatment. This procedure will methylate the SiO2. Of
course, you will also have to functionalize your SiO2 if you run a column.

Brandon

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Next message: Jeremy M. Carr: "Re: ORGLIST: Swern vs. Dess Martin"
Previous message: Peng Gao: "ORGLIST: How to make this reaction work?"
Maybe in reply to: Ken Knott: "ORGLIST: Neutralizing TLC plates?"

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