Re: ORGLIST: Neutralizing TLC plates?

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From: Brandon M. Vogel (bvogel95$##$gmail.com)
Date: Wed Apr 11 2007 - 23:12:11 EDT


Ken Knott wrote:
> I have a compound that I think may be degrading on TLC plates due to
> the mild acidity.
>
> I would appreciate advice on how to neutralize TLC plates prior to
> running them. I understand that this can be done with a 1% solution
> of TEA in your eluent prior to running the compound? Can anyone offer
> any suggestions or advice on doing this?
>
> Also, how might I make myself more certain that I am in fact
> witnessing degradation of my compound as a result of running it on the
> TLC?
>
> Thanks in advance!
>
> Ken
>
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You may try passivating the TLC plate with hexamethyl disilazane (HMDS)
via a vapor treatment. This procedure will methylate the SiO2. Of
course, you will also have to functionalize your SiO2 if you run a column.

Brandon


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