From: Ohad Ilovich (ilovich$##$pob.huji.ac.il)
Date: Thu Apr 26 2007 - 10:35:28 EDT
Dear all
I wish to preform an amidation reaction on a carboxylic acid. This can be done in two ways i know of:
1) creation of the acid chloride and then a reaction with the amine
2) direct reaction with an amine in the presance of a dehydrating agent such as DCC or DIC.
I wish to do the amidation with ammonia but it is expensive so i thought of using ammonium hydroxide in an aqueous phase.
Does anyone have any expirience with these reagent? any articles in the subject?
by the way i'm not working in solid phase....
Thanks in advance
Ohad Ilovich
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