From: Ohad Ilovich (ilovich$##$pob.huji.ac.il)
Date: Mon Mar 19 2007 - 06:59:36 EDT
a simple search in goole scholar ("selective debenzylation n-benzyl o-benzyl") can get you a few articles
I think DEAD is hard to aquire and DIAD is a good replacement (though it could lead to better yields)
Pd(OH)2 is something i worked with myself and actually debenzylated O-benzyls (but i used a 50% weight ratio and i didn't have any N-benzyls so maybe it reacts much faster with those)
Good Luck
Ohad
----- Original Message -----
From: Mugunthan G
To: everybody$##$orglist.net
Sent: Sunday, March 18, 2007 6:27 PM
Subject: ORGLIST: selective N-debenzylation
Hi friends,
Is there any method to selectively remove N-benzyl groups in presence of O-benzyl ethers.....
MUGUNTHAN.G
DEPARTMENT OF MEDICINAL CHEMISTRY
NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND REASEARCH
SECTOR-67,PHASE-10, MOHALI
PUNJAB-160062
INDIA
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