Re: ORGLIST: TLC help - monitoring a reaction

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From: Sarbjit Singh (sabbykular$##$gmail.com)
Date: Tue Feb 13 2007 - 13:01:54 EST


Dear
The easiest thing you should try first is developing the reaction TLC
in Iodine Chamber and if it fails try other things suggested by
fellows
Regards
Sarbjit

On 2/5/07, Sachin Chaphekar <purvi_chaphekar$##$yahoo.com> wrote:
> Hi!
>
> TLC should not be a problem, since MMA is not that volatile. I had a look in
> other suggestions you got, treating with KMnO4 sounds a very good idea.
> However in my experience instead of dipping TLC in soln. spray the KMnO4
> over TLC the spots appear more distinct this way.
> Also if everything else fails what you can also do is check your reacn mass
> sample by a dilute bromine solution. MMA will decolourise bromine solution
> (bromine is added on the double bond of MMA), in absence or low
> concentrations it will not. But be careful about the quantity of bromine
> soln. you will use.
>
> Sachin
>
>
> ----- Original Message ----
> From: Ken Knott <esprcorn$##$hotmail.com>
> To: everybody$##$orglist.net
> Sent: Friday, February 2, 2007 10:46:09 AM
> Subject: ORGLIST: TLC help - monitoring a reaction
>
>
> Ok, easy one again for ya guys...
>
> Again, I'm a 1st year grad student so I'm still struggling with some of the
> basics...
>
> I'm running a reaction where I'm supposed to monitor the disappearance of
> the starting material (methyl methacrylate) by TLC. I'm using a reaction
> scheme/protocol from another paper. But methy methacrylate appears to be
> very limitedly UV active and very volatile. So I can't really see the spot
> and even if I could it evaporates before it can elute. I think...
>
> Before realizing this I tried monitoring on GC in the lab, but I didn't get
> anything.. Again, likely due to the volatility of methyl methacrylate....
>
> Is there another way I can monitor the consumption of the methyl
> methacrylate? Or will I have to settle for monitoring the product possibly?
> Or just give it 24 hours and work it up crossing my fingers?
>
> In the paper where I got the reaction, their substrates are all UV active
> and non-volatile so this was not an issue for them.
>
> This is fun stuff... but I'm stumped...
>
> Thanks!!
>
> Ken
>
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