ORGLIST: Fw: Alkylation with Ph-Et-Br

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From: THT (medichemtang$##$263.net)
Date: Wed Nov 22 2006 - 14:58:01 EST

Hi Kamal:

Mabye NaH(2 mol) as base, ans THF(add some HPMT) as solvent is work.
----- Original Message -----
From: Kamal Morendha
To: everybody$##$orglist.net
Sent: Wednesday, November 22, 2006 7:27 PM
Subject: ORGLIST: Alkylation with Ph-Et-Br


Hi !

I'm doing one alkylation reaction involving N-Ethoxycarbonylmethyl-L-Valine & 2-Phenylethyl Bromide as under :


EtOOC-CH2-NHCH-CH(CH3)2-COOH + 2-PhCH2CH2Br -------> EtOOC-CH(CH2CH2Ph)-NHCH-CH(CH3)2-COOH


I tried using K2CO3 in diff. solvents, Na-EtOH, but could not get the conversion at all.

May I get some suggetions for this Alkylation ?



Thanks,
Kamal




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