ORGLIST: Alkylation with Ph-Et-Br

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From: Kamal Morendha (mailbox$##$prolificint.com)
Date: Wed Nov 22 2006 - 06:27:14 EST

Hi !

I'm doing one alkylation reaction involving N-Ethoxycarbonylmethyl-L-Valine & 2-Phenylethyl Bromide as under :

EtOOC-CH2-NHCH-CH(CH3)2-COOH + 2-PhCH2CH2Br -------> EtOOC-CH(CH2CH2Ph)-NHCH-CH(CH3)2-COOH

I tried using K2CO3 in diff. solvents, Na-EtOH, but could not get the conversion at all.

May I get some suggetions for this Alkylation ?

Thanks,
Kamal

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