ORGLIST: Formation of cyanohydrine on substituted beta keto ester.

Date view Thread view Subject view Author view Attachment view

From: prakash$##$tricheminc.net
Date: Sat Oct 28 2006 - 23:56:22 EDT

Dear Sir
We are conducting a cyanation reaction on beta keto ester where active
methylene group is alkylated with ethyl group.Known methods to form a
cyanohydrine is formation of bisulfite adduct with the help of sodium
bisulfite followed by cyanation with sodium cyanide at low temperature.We
have tried almost all the referencec cited in the literature of particular
product.We found that bisulfite adduct is not forming at all.
We have tried the above reaction by altering molar ratio , temperature ,
mode of addition ,changing the sodium bisulfite.
Please send your valuable suggestions.

Regards:

Prakash Chavan
Director R&D

Office phone:+912525 271022
Mobile : +919960604662
  

--------------------------------------------------------------------
mail2web - Check your email from the web at
http://mail2web.com/ .

_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address

Date view Thread view Subject view Author view Attachment view

This archive was generated by hypermail 2.1.4 : Tue Feb 13 2007 - 14:17:01 EST