From: Sengen Sun (sengensun$##$yahoo.com)
Date: Tue Oct 03 2006 - 15:25:18 EDT
It is very hard indeed. In similarly cases, I always
reduce azido group with triethylphosphine in
MeCN/water = 9:1, rt, O/N. It is an easy reaction,
even although the cost is some higher in the large
scale than hydrogenation.
Sengen
--- Jeff Li <arnombas$##$yahoo.com.cn> wrote:
> Does any one know how to hydrogenate an azido group
> without affecting the benzyloxy group in a
> molecule?
>
> I've tried using Pd-C in the solvent of EtOAc, but
> it seemed that it was not really easy to control on
> a large scale.
>
> I'll appreciate for your advice.
>
>
> ---------------------------------
> ÇÀ×¢ÑÅ»¢Ãâ·ÑÓÊÏä-3.5GÈÝÁ¿£¬20M¸½¼þ£¡ >
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