ORGLIST: Ugi Reaction

Date view Thread view Subject view Author view Attachment view

From: sea urchin (epoxidation$##$gmail.com)
Date: Thu Sep 07 2006 - 20:50:55 EDT

Hi all !!

I am trying to perform a Ugi reaction. The aliphatic aldehyde that I am
using is attached to an o-cresol group, the amino acid is N-protected with
BOC group, the amine is aliphatic also and I am trying Benzyl isocyanide.
The reaction is supposed to be run in methanol . However
even after 24hrs at room temp, I am able to obtain absolutely nothing of the
expected product a (diamide) di-peptide.
I have also tried doing this reaction with simpler reactants ( formaldehyde,
Boc-glycine, tert-butyl amine, and 2-morpholin ethyl isocyanide),
ufortunately that didn't work either.

Do any of you have any suggestions as to what can be done to make the
product appear..

Your suggestions are highly appreciated.

Thanks

Epoxidation.


_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address

Date view Thread view Subject view Author view Attachment view

This archive was generated by hypermail 2.1.4 : Tue Feb 13 2007 - 14:17:01 EST