ORGLIST: Condensation

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From: shrent (shrent$##$rediffmail.com)
Date: Sat Jun 24 2006 - 09:29:36 EDT

Hi ! I'm doing one condensation reaction between alanine-t-butyl/benzyl ester & an alpha-bromoester as under : PhCH2CH2CH(Br)COOC2H5 + CH3CH(NH2)COOR to PhCH2CH2(COOC2H5)CHNHCH(CH3)COOR where, R=Benzyl/t-butyl. i.e. eliminating HBr in this reaction. But unfortunately, I have just one reference route for this using acetonitrile as solvent & adding TEA & both of the reactants, all in eq.molar prop. & reflux for over 2 days.....But still not getting good conversion & desired purity of final compound..... Can I pls get any other route for such condensation ?   Awaiting your reply ! Warm regards, shrent Baroda, India.


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