From: Guido de Silvestri (guidods$##$etb.net.co)
Date: Wed May 03 2006 - 12:51:12 EDT
Dear Madhav...
This kind of processes has to be carrying about within two stages:
As a first step, a synthesis of an alkylhalide from the alcohol can be
possible using thionyl chloride:
ROH +SOCL2 = RCl+SO2 +HCl
Here, pyridine is used as an alkaline absorption agent, yielding the HCl
to pyridine chloride
In a second stage, the alkyl halide (that it is easy to separate from
the reaction mixture), could react with a metallic hydrosulfide making a
nucleophylic substitution, into an alcoholic solution:
RCl + NaSH = RSH + NaCl
In addition, this process is very useful to the primaries merchaptans
synthesis, but not when a secondary or a tertiary halide is involved,
because those could be easy deydrogenalized in presence of strong bases.
Best regards,
Guido de Silvestri
Process Engineer
-----Mensaje original-----
De: everybody-bounces$##$orglist.net [mailto:everybody-bounces$##$orglist.net]
En nombre de madhav mallia
Enviado el: Miércoles, 03 de Mayo de 2006 06:16 a.m.
Para: everybody$##$orglist.net
Asunto: ORGLIST: conversion of OH group to SH
i want to convert aliphatic alcohol to thiol. what are
the options available? help needed.
thanks in advance
madhav
___________________________________________________________
To help you stay safe and secure online, we've developed the all new
Yahoo! Security Centre. http://uk.security.yahoo.com
_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message:
unsubscribe your_orglist_password your_address
_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address
This archive was generated by hypermail 2.1.4 : Tue Feb 13 2007 - 14:17:01 EST