From: Ravi Orugunty (rorugunty$##$oragenics.com)
Date: Thu Mar 02 2006 - 13:09:52 EST
Try adding catalytic amounts of acid either HCl or Trifluoroacetic acid. It
should give you a better rate of reaction as well as formation of product.
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Today's Topics:
1. Michael addition (shrent)
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Message: 1
Date: 2 Mar 2006 09:56:16 -0000
From: "shrent" <shrent$##$rediffmail.com>
Subject: ORGLIST: Michael addition
To: everybody$##$orglist.net
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Hello !
I'm trying one Michael addition reaction between an acrylate based ester
with l-alanine as under.
Ph-CO-CH=CH-COOC2H5 + H2N-CH(CH3)-COOH makes :
Ph-CO-CH2-CH(COOC2H5)-NH-CH(CH3)-COOH.
But here, the solubility of l-alanine inhibits taking reaction in any
solvent like Methanol/ethanol, etc.
Can you suggest something like, solvent media, solbility of l-alanine &
other reaction conditions ?
Regards,
SHRENT
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