ORGLIST: Michael addition

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From: shrent (shrent$##$rediffmail.com)
Date: Thu Mar 02 2006 - 04:56:16 EST

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Hello ! I'm trying one Michael addition reaction between an acrylate based ester with l-alanine as under. Ph-CO-CH=CH-COOC2H5 + H2N-CH(CH3)-COOH makes : Ph-CO-CH2-CH(COOC2H5)-NH-CH(CH3)-COOH. But here, the solubility of l-alanine inhibits taking reaction in any solvent like Methanol/ethanol, etc. Can you suggest something like, solvent media, solbility of l-alanine & other reaction conditions ? Regards, SHRENT

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