ORGLIST: RE: Everybody Digest, Vol 18, Issue 14

rorugunty$##$oragenics.com

--
Eugen* Leitl leitl http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820            http://www.ativel.com
8B29F6BE: 099D 78BA 2FD3 B014 B08A  7779 75B0 2443 8B29 F6BE
------------------------------
Message: 3
Date: Tue, 21 Feb 2006 17:26:22 -0500
From: "Kiessling, Dr Anthony J" <akiessli$##$mansfield.edu>
Subject: RE: ORGLIST: Synthetic Methods Wiki
To: "Eugen Leitl" <eugen$##$leitl.org>, <everybody$##$orglist.net>
Message-ID:
	<BEBF113AABFE1940A2770CC58C611EC0307233$##$exchange01.facstaff.mansfield.edu>
Content-Type: text/plain;	charset="us-ascii"
I guess I might be a little dense here but it seems to me that what you
are looking for already exists, it's called a library. I took a look at
the synthetic web site that was mentioned a few notes ago and thought it
reminded me of Organic Synthesis's little brother, BUT it's not peer
reviewed. As a synthetic organic chemist I would not trust this site as
much as I would Organic Synthesis, or a procedure gleaned from J. Org.
Chem. or any other ACS publication. ACS publications are already
searchable on the web, yes I know it cost an annual due but it is there.
As for the copyright issue, that is common and the ACS and other
publication houses own copyright to all published procedures. As for
more general knowledge, there are books published on practical organic
chemistry (Larock, March, Carey & Sunberg, Shriner's qual text, etc.).
Drying solvents was the first thing I learned to do when I arrived at
grad school. As the old saying goes, '40 hours in the lab will save you
an hour in the library'.
Dr. Kiessling
Department of Chemistry
Mansfield University
570-662-4546
akiessli$##$mansfield.edu
http://faculty.mansfield.edu/akiessli/
-----Original Message-----
From: everybody-bounces$##$orglist.net
[mailto:everybody-bounces$##$orglist.net] On Behalf Of Eugen Leitl
Sent: Tuesday, February 21, 2006 2:08 PM
To: everybody$##$orglist.net
Subject: Re: ORGLIST: Synthetic Methods Wiki
On Tue, Feb 21, 2006 at 07:54:57PM +0100, Jonas Sundberg wrote:
> Yes, that looks like a big problem.
I wonder what the motivation behind this restrictive copyright
was. Do the operators of http://www.syntheticpages.org/ (I kept
looking for a contact address, but was unable to find any) eventually
intend to raise a profit from operating it?
> But I think it will be hard to get traffic/active writers, as there
seem
> to be a lack of organic chemists that surf the web. Still I think it's
> worth a try! It doesn't cost anything else than the time wasted
setting
> it up, and it could both be fun and educative. But I think we need
more
> than a wiki of organic synthesis. A think a general wiki about organic
> chemistry with a special section dedicated to preparatory methods
would
> work better, and maybe run a forum too.
I'm a chemist by training, currently work in cheminformatics, and
have several machines in the rack by way of hobby. Assuming people here
would contribute content, we can easily cook up something useful, and
then see
where it goes from there. There's plenty of such projects in biological
sciences (e.g. http://openwetware.org/wiki/Main_Page etc.), but I always
considered organic chemists to be a too conservative bunch.
Is there at all an interest here in such a project?
> /Jonas
>
> Eugen Leitl wrote:
>
> >On Mon, Feb 20, 2006 at 06:46:45PM +0000, will jones wrote:
> >
> >
> >
> >>I've tried using that site before and also found it a bit thin. If
you
> >>
> >>
> >
> >I see bigger problems here:
http://www.syntheticpages.org/static/terms.php
> >
> >Copyright
> >
> >   * SyntheticPages owns the copyright and any other rights to all
> >   materials on this website
> >   * SyntheticPages authorises you to:
> >         o browse and download the material
> >         o print out the material for teaching or research
activities,
> >         provided that the copyright notice is included (Copyright
> >         SyntheticPages (c) )
> >   * You are not authorised to:
> >         o alter the material in any way
> >         o reproduce or store any part of this web site in any other
> >         public or private storage medium, electronic or otherwise,
> >         without written permission from SyntheticPages.
> >
> >
> >
> >
> >>could make the submission process easy, and somehow have the ability
to
> >>search by structure, then I guess you would be onto a winner.
> >>
> >>
> >
> >These are GIFs, so in order to be able to search the images would
> >have to be reentered manually, and exported into a suitable format
> >(SMILEs, InChI, SDF, etc.) for searching (in a pinch, obgrep would
do).
> >
> >
> >
> >>If you could also put in a 'section of failed reactions, but should
have
> >>worked' then that would be awesome.
> >>
> >>
> >
> >
> >
>
> _______________________________________________
> ORGLIST - Organic Chemistry Mailing List
> Website / Archive / FAQ: http://www.orglist.net
> To post a message (TO EVERYBODY) send to everybody$##$orglist.net
> To unsubscribe, send to everybody-request$##$orglist.net the message:
> unsubscribe your_orglist_password your_address
--
Eugen* Leitl leitl http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820            http://www.ativel.com
8B29F6BE: 099D 78BA 2FD3 B014 B08A  7779 75B0 2443 8B29 F6BE
_______________________________________________
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To post a message (TO EVERYBODY) send to everybody$##$orglist.net
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------------------------------
Message: 4
Date: Tue, 21 Feb 2006 14:16:08 -0800 (PST)
From: Sengen Sun <sengensun$##$yahoo.com>
Subject: ORGLIST: A breakthrough in mechanism of concerted
	cycloadditions?
To: everybody$##$orglist.net
Message-ID: <20060221221608.62705.qmail$##$web53706.mail.yahoo.com>
Content-Type: text/plain; charset=iso-8859-1
Recently, I claimed that I have made a breakthrough in
the fundamental understanding of concerted
cycloadditions.
Now I have uploaded to the CCL site one of my papers
and a ppt presentation I used twice in 2005 for two
international symposiums. The paper was the first
paper I posted in the Chemistry Preprint Server 5
years ago. Some people already have it.
http://server.ccl.net/cca/documents/ConcertedCycloadditons/
http://server.ccl.net/cca/documents/ConcertedCycloadditons_2/
My findings on the theoretical knowledge of concerted
cycloadditions are based on such a "ridiculously"
simple method that it may be simply ridiculous to some
people. I evaluated some arbitrary colliding complexes
and learned some new and very important knowledge that
is valid in understanding the concerted pathway. I
formulated some new and interesting concepts such as
conjugation hindrances and easiness of electronic
migration that decide organic chemical reactivity.
I invite every one to criticize my theory on a
scientific basis. I invite you to defeat my
sensational claims I made in the Conclusions of my ppt
presentation. If I am convinced anything I made wrong,
I will correct or withdraw it.
Thanks to every one.
Sengen
__________________________________________________
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Tired of spam?  Yahoo! Mail has the best spam protection around
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------------------------------
Message: 5
Date: Wed, 22 Feb 2006 11:42:33 -0000
From: "Clyde Davies" <deadlyvices$##$hotmail.com>
Subject: RE: ORGLIST: Synthetic Methods Wiki
To: <everybody$##$orglist.net>
Message-ID: <BAY107-DAV14D8CA7D37C98B893C2365B4FD0$##$phx.gbl>
Content-Type: text/plain;	charset="us-ascii"
I have to say that I do take issue with this standpoint.  Firstly, I no
longer work in chemistry research but I still maintain an interest so access
to a library is a no-no as far as I am concerned.  Secondly, not everything
useful gets published, and not everything published is useful.  I went
through countless organic chemistry manuals trying to find out what the hell
I was doing wrong in my tetracyanobenzene synthesis.  Each manual said for
me to dry my DMF using molecular sieves, which I did, and which had little
effect (unknown to me).  I got lucky once, evidently, but it wasn't until I
spoke a couple of years later to a proper organic (not a physical chemist)
who pointed out the flaw in my experimental methodology.  In the meantime, I
had developed my own very mild and effective but expensive synthesis of
tetracyanobenzene which was ALSO not published because it was part of a
larger piece of work which ended up being pretty bloody pointless.
As regards provenance, the syntheses in Organic Syntheses *are* checked, but
these are in the minority.  How many times do we read in the literature of
'an improved/procedure/method for synthesis of...'?  It's been quite evident
that the authors of such papers are disappointed by the discrepancy between
reported yields and their own actual ones.  I am proposing that such a site
would *compliment* and not *replace* the peer-reviewed method of publishing.
Besides, if you don't like what you read, you can change it.  That's the
beauty of this particular publishing mindset, and one of the reasons why
Wikipedia is successful *and* reliable.  If this resource can prevent *one*
grad student going through the hell that I went through trying to prepare
one compound then I think it worth the risk.
Dr. Clyde Davies
-----Original Message-----
From: everybody-bounces$##$orglist.net [mailto:everybody-bounces$##$orglist.net]
On Behalf Of Kiessling, Dr Anthony J
Sent: 21 February 2006 22:26
To: Eugen Leitl; everybody$##$orglist.net
Subject: RE: ORGLIST: Synthetic Methods Wiki
I guess I might be a little dense here but it seems to me that what you
are looking for already exists, it's called a library. I took a look at
the synthetic web site that was mentioned a few notes ago and thought it
reminded me of Organic Synthesis's little brother, BUT it's not peer
reviewed. As a synthetic organic chemist I would not trust this site as
much as I would Organic Synthesis, or a procedure gleaned from J. Org.
Chem. or any other ACS publication. ACS publications are already
searchable on the web, yes I know it cost an annual due but it is there.
As for the copyright issue, that is common and the ACS and other
publication houses own copyright to all published procedures. As for
more general knowledge, there are books published on practical organic
chemistry (Larock, March, Carey & Sunberg, Shriner's qual text, etc.).
Drying solvents was the first thing I learned to do when I arrived at
grad school. As the old saying goes, '40 hours in the lab will save you
an hour in the library'.
Dr. Kiessling
Department of Chemistry
Mansfield University
570-662-4546
akiessli$##$mansfield.edu
http://faculty.mansfield.edu/akiessli/
-----Original Message-----
From: everybody-bounces$##$orglist.net
[mailto:everybody-bounces$##$orglist.net] On Behalf Of Eugen Leitl
Sent: Tuesday, February 21, 2006 2:08 PM
To: everybody$##$orglist.net
Subject: Re: ORGLIST: Synthetic Methods Wiki
On Tue, Feb 21, 2006 at 07:54:57PM +0100, Jonas Sundberg wrote:
> Yes, that looks like a big problem.
I wonder what the motivation behind this restrictive copyright
was. Do the operators of http://www.syntheticpages.org/ (I kept
looking for a contact address, but was unable to find any) eventually
intend to raise a profit from operating it?
> But I think it will be hard to get traffic/active writers, as there
seem
> to be a lack of organic chemists that surf the web. Still I think it's
> worth a try! It doesn't cost anything else than the time wasted
setting
> it up, and it could both be fun and educative. But I think we need
more
> than a wiki of organic synthesis. A think a general wiki about organic
> chemistry with a special section dedicated to preparatory methods
would
> work better, and maybe run a forum too.
I'm a chemist by training, currently work in cheminformatics, and
have several machines in the rack by way of hobby. Assuming people here
would contribute content, we can easily cook up something useful, and
then see
where it goes from there. There's plenty of such projects in biological
sciences (e.g. http://openwetware.org/wiki/Main_Page etc.), but I always
considered organic chemists to be a too conservative bunch.
Is there at all an interest here in such a project?
> /Jonas
>
> Eugen Leitl wrote:
>
> >On Mon, Feb 20, 2006 at 06:46:45PM +0000, will jones wrote:
> >
> >
> >
> >>I've tried using that site before and also found it a bit thin. If
you
> >>
> >>
> >
> >I see bigger problems here:
http://www.syntheticpages.org/static/terms.php
> >
> >Copyright
> >
> >   * SyntheticPages owns the copyright and any other rights to all
> >   materials on this website
> >   * SyntheticPages authorises you to:
> >         o browse and download the material
> >         o print out the material for teaching or research
activities,
> >         provided that the copyright notice is included (Copyright
> >         SyntheticPages (c) )
> >   * You are not authorised to:
> >         o alter the material in any way
> >         o reproduce or store any part of this web site in any other
> >         public or private storage medium, electronic or otherwise,
> >         without written permission from SyntheticPages.
> >
> >
> >
> >
> >>could make the submission process easy, and somehow have the ability
to
> >>search by structure, then I guess you would be onto a winner.
> >>
> >>
> >
> >These are GIFs, so in order to be able to search the images would
> >have to be reentered manually, and exported into a suitable format
> >(SMILEs, InChI, SDF, etc.) for searching (in a pinch, obgrep would
do).
> >
> >
> >
> >>If you could also put in a 'section of failed reactions, but should
have
> >>worked' then that would be awesome.
> >>
> >>
> >
> >
> >
>
> _______________________________________________
> ORGLIST - Organic Chemistry Mailing List
> Website / Archive / FAQ: http://www.orglist.net
> To post a message (TO EVERYBODY) send to everybody$##$orglist.net
> To unsubscribe, send to everybody-request$##$orglist.net the message:
> unsubscribe your_orglist_password your_address
--
Eugen* Leitl leitl http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820            http://www.ativel.com
8B29F6BE: 099D 78BA 2FD3 B014 B08A  7779 75B0 2443 8B29 F6BE
_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message:
unsubscribe your_orglist_password your_address
_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message:
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------------------------------
Message: 6
Date: Wed, 22 Feb 2006 11:22:28 +0000
From: nigel$##$pierpoint.u-net.com
Subject: Re: ORGLIST: Synthetic Methods Wiki
To: Eugen Leitl <eugen$##$leitl.org>
Cc: everybody$##$orglist.net
Message-ID: <E1FBs4j-0004HC-Qt$##$he107war.uk.vianw.net>
Content-Type: text/plain; format=flowed; charset="iso-8859-1"
As a purely UK web based operation
(http://www.syntheticpages.org/static/pwstatement.html)
its not unreasonable to expect communication to be performed via email,
hence
editor$##$syntheticpages.org.
would be the obvious place to contact them.
Maybe someone should forward these comments onto the editors and see if
there is a response.
I don't really think it is a huge problem with copyright.
Don't you reference other authors when you use their work/ideas in your own
research especially when writing papers?
Also when references the site it helps publicise it which would advertise it
to a larger audience and possibly increase the number of submissions.
As to accessing books and journals to glean information about procedures,
how many of you have been performing a reaction done countless times in the
lab before but by someone else and you can't get it to work? You're
following the prep word by word but still can't recreate the ideal
conditions that ensures 100 % yield!
Only when you ask that person do they say (Oh actually I found
that........does the trick). This information is not included in the
original prep, nor written up else where.
Its this "trivial" information that Syntheticpages tries to fill and
remember it FREE!!!
Cheers
Nigel
Eugen Leitl writes:
> On Tue, Feb 21, 2006 at 07:54:57PM +0100, Jonas Sundberg wrote:
>
>> Yes, that looks like a big problem.
>
> I wonder what the motivation behind this restrictive copyright
> was. Do the operators of http://www.syntheticpages.org/ (I kept
> looking for a contact address, but was unable to find any) eventually
> intend to raise a profit from operating it?
>
>> But I think it will be hard to get traffic/active writers, as there seem
>> to be a lack of organic chemists that surf the web. Still I think it's
>> worth a try! It doesn't cost anything else than the time wasted setting
>> it up, and it could both be fun and educative. But I think we need more
>> than a wiki of organic synthesis. A think a general wiki about organic
>> chemistry with a special section dedicated to preparatory methods would
>> work better, and maybe run a forum too.
>
> I'm a chemist by training, currently work in cheminformatics, and
> have several machines in the rack by way of hobby. Assuming people here
> would contribute content, we can easily cook up something useful, and then
see
> where it goes from there. There's plenty of such projects in biological
> sciences (e.g. http://openwetware.org/wiki/Main_Page etc.), but I always
> considered organic chemists to be a too conservative bunch.
>
> Is there at all an interest here in such a project?
>
>> /Jonas
>>
>> Eugen Leitl wrote:
>>
>> >On Mon, Feb 20, 2006 at 06:46:45PM +0000, will jones wrote:
>> >
>> >
>> >
>> >>I've tried using that site before and also found it a bit thin. If you
>> >>
>> >>
>> >
>> >I see bigger problems here:
http://www.syntheticpages.org/static/terms.php
>> >
>> >Copyright
>> >
>> >   * SyntheticPages owns the copyright and any other rights to all
>> >   materials on this website
>> >   * SyntheticPages authorises you to:
>> >         o browse and download the material
>> >         o print out the material for teaching or research activities,
>> >         provided that the copyright notice is included (Copyright
>> >         SyntheticPages ) )
>> >   * You are not authorised to:
>> >         o alter the material in any way
>> >         o reproduce or store any part of this web site in any other
>> >         public or private storage medium, electronic or otherwise,
>> >         without written permission from SyntheticPages.
>> >
>> >
>> >
>> >
>> >>could make the submission process easy, and somehow have the ability to
>> >>search by structure, then I guess you would be onto a winner.
>> >>
>> >>
>> >
>> >These are GIFs, so in order to be able to search the images would
>> >have to be reentered manually, and exported into a suitable format
>> >(SMILEs, InChI, SDF, etc.) for searching (in a pinch, obgrep would do).
>> >
>> >
>> >
>> >>If you could also put in a 'section of failed reactions, but should
have
>> >>worked' then that would be awesome.
>> >>
>> >>
>> >
>> >
>> >
>>
>> _______________________________________________
>> ORGLIST - Organic Chemistry Mailing List
>> Website / Archive / FAQ: http://www.orglist.net
>> To post a message (TO EVERYBODY) send to everybody$##$orglist.net
>> To unsubscribe, send to everybody-request$##$orglist.net the message:
>> unsubscribe your_orglist_password your_address
> --
> Eugen* Leitl leitl http://leitl.org
> ______________________________________________________________
> ICBM: 48.07100, 11.36820            http://www.ativel.com
> 8B29F6BE: 099D 78BA 2FD3 B014 B08A  7779 75B0 2443 8B29 F6BE
> _______________________________________________
> ORGLIST - Organic Chemistry Mailing List
> Website / Archive / FAQ: http://www.orglist.net
> To post a message (TO EVERYBODY) send to everybody$##$orglist.net
> To unsubscribe, send to everybody-request$##$orglist.net the message:
unsubscribe your_orglist_password your_address
------------------------------
Message: 7
Date: Wed, 22 Feb 2006 15:43:36 -0000
From: "Clyde Davies" <deadlyvices$##$hotmail.com>
Subject: RE: ORGLIST: Synthetic Methods Wiki
To: <nigel$##$pierpoint.u-net.com>, "'Eugen Leitl'" <eugen$##$leitl.org>
Cc: everybody$##$orglist.net
Message-ID: <BAY107-DAV1203BA947C295182C1454FB4FD0$##$phx.gbl>
Content-Type: text/plain;	charset="us-ascii"
I have to say that I find the notion that copyright of a chemical procedure
that is to say that it is impossible to reproduce the same procedure word
-for-word in another format -  residing totally with the publisher to be
absolutely preposterous.
I think the problem with Synthetic Pages is that it is taking 20th century
notions of scientific publishing and trying to apply them to a very 21st
century medium - the Internet.  Peer-review existed back in the days of the
printed page to ensure that the quality of the material being published was
sufficient before committing it to the expensive process of printing.  Now,
with a wiki, if something proves to be wrong we can retrospectively correct
it.  My only concern is to do with *safety* issues:  advocating the
sloshing-about of trichloromethyl chloroformate without pointing out that it
generates phosgene vapour, for example would be very irresponsible.
So I think that the reason why Synthetic Pages is as thin as it is, is
simply because the process does not 'leverage' the inherently flexible and
dynamic nature of the medium.  There is still a submissions procedure, peer
review, predefined (and rigid) format etc etc...none of which makes the
slightest acknowledgement that there are new and better ways of doing things
now.
>>From the (largely positive) feedback I have received here I will be
progressing with this project.  A number of people have already pledged
their support (you know who you are) and I will be contacting them shortly
to see how we take this idea forward, resources permitting.
Dr Clyde Davies
-----Original Message-----
From: everybody-bounces$##$orglist.net [mailto:everybody-bounces$##$orglist.net]
On Behalf Of nigel$##$pierpoint.u-net.com
Sent: 22 February 2006 11:22
To: Eugen Leitl
Cc: everybody$##$orglist.net
Subject: Re: ORGLIST: Synthetic Methods Wiki
As a purely UK web based operation
(http://www.syntheticpages.org/static/pwstatement.html)
its not unreasonable to expect communication to be performed via email,
hence
editor$##$syntheticpages.org.
would be the obvious place to contact them.
Maybe someone should forward these comments onto the editors and see if
there is a response.
I don't really think it is a huge problem with copyright.
Don't you reference other authors when you use their work/ideas in your own
research especially when writing papers?
Also when references the site it helps publicise it which would advertise it
to a larger audience and possibly increase the number of submissions.
As to accessing books and journals to glean information about procedures,
how many of you have been performing a reaction done countless times in the
lab before but by someone else and you can't get it to work? You're
following the prep word by word but still can't recreate the ideal
conditions that ensures 100 % yield!
Only when you ask that person do they say (Oh actually I found
that........does the trick). This information is not included in the
original prep, nor written up else where.
Its this "trivial" information that Syntheticpages tries to fill and
remember it FREE!!!
Cheers
Nigel
Eugen Leitl writes:
> On Tue, Feb 21, 2006 at 07:54:57PM +0100, Jonas Sundberg wrote:
>
>> Yes, that looks like a big problem.
>
> I wonder what the motivation behind this restrictive copyright
> was. Do the operators of http://www.syntheticpages.org/ (I kept
> looking for a contact address, but was unable to find any) eventually
> intend to raise a profit from operating it?
>
>> But I think it will be hard to get traffic/active writers, as there seem
>> to be a lack of organic chemists that surf the web. Still I think it's
>> worth a try! It doesn't cost anything else than the time wasted setting
>> it up, and it could both be fun and educative. But I think we need more
>> than a wiki of organic synthesis. A think a general wiki about organic
>> chemistry with a special section dedicated to preparatory methods would
>> work better, and maybe run a forum too.
>
> I'm a chemist by training, currently work in cheminformatics, and
> have several machines in the rack by way of hobby. Assuming people here
> would contribute content, we can easily cook up something useful, and then
see
> where it goes from there. There's plenty of such projects in biological
> sciences (e.g. http://openwetware.org/wiki/Main_Page etc.), but I always
> considered organic chemists to be a too conservative bunch.
>
> Is there at all an interest here in such a project?
>
>> /Jonas
>>
>> Eugen Leitl wrote:
>>
>> >On Mon, Feb 20, 2006 at 06:46:45PM +0000, will jones wrote:
>> >
>> >
>> >
>> >>I've tried using that site before and also found it a bit thin. If you
>> >>
>> >>
>> >
>> >I see bigger problems here:
http://www.syntheticpages.org/static/terms.php
>> >
>> >Copyright
>> >
>> >   * SyntheticPages owns the copyright and any other rights to all
>> >   materials on this website
>> >   * SyntheticPages authorises you to:
>> >         o browse and download the material
>> >         o print out the material for teaching or research activities,
>> >         provided that the copyright notice is included (Copyright
>> >         SyntheticPages C )
>> >   * You are not authorised to:
>> >         o alter the material in any way
>> >         o reproduce or store any part of this web site in any other
>> >         public or private storage medium, electronic or otherwise,
>> >         without written permission from SyntheticPages.
>> >
>> >
>> >
>> >
>> >>could make the submission process easy, and somehow have the ability to
>> >>search by structure, then I guess you would be onto a winner.
>> >>
>> >>
>> >
>> >These are GIFs, so in order to be able to search the images would
>> >have to be reentered manually, and exported into a suitable format
>> >(SMILEs, InChI, SDF, etc.) for searching (in a pinch, obgrep would do).
>> >
>> >
>> >
>> >>If you could also put in a 'section of failed reactions, but should
have
>> >>worked' then that would be awesome.
>> >>
>> >>
>> >
>> >
>> >
>>
>> _______________________________________________
>> ORGLIST - Organic Chemistry Mailing List
>> Website / Archive / FAQ: http://www.orglist.net
>> To post a message (TO EVERYBODY) send to everybody$##$orglist.net
>> To unsubscribe, send to everybody-request$##$orglist.net the message:
>> unsubscribe your_orglist_password your_address
> --
> Eugen* Leitl leitl http://leitl.org
> ______________________________________________________________
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Message: 8
Date: Wed, 22 Feb 2006 10:45:06 -0500
From: "Robert J. Panetta" <rj_panet$##$alcor.concordia.ca>
Subject: ORGLIST: Is methylation in water possible?
To: everybody$##$orglist.net
Message-ID: <1140623106.43fc8702e6627$##$alcor.concordia.ca>
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Hi all,
I'm interested in methylating a suite of carboxylic acids (ranging from
acetic
to mellitic), which are initially dissolved in water. Just to make life
easier
and eliminate a few steps in my procedures, I was wondering if anyone here
knows of a methylation (or any alkylation reagent) which is not water
sensitive. Is such a reagent even a possibility?
Thanks,
Robert
--
Robert J. Panetta
Dept. Chemistry and Biochemistry
Concordia University
rj_panet$##$alcor.concordia.ca
(514)848-2424 ext. 7972
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