ORGLIST: RE: Everybody Digest, Vol 14, Issue 9

Date view Thread view Subject view Author view Attachment view

From: Ravi Orugunty (rorugunty$##$oragenics.com)
Date: Wed Nov 16 2005 - 14:29:49 EST


Hi Kamal

By reading the information that you have provided it seems to me that you
are trying to crysatllize the amine and recover your solvent. It also seems
to me that you are using concentrated HCl. If that is the case then here is
an alternative solution.
Use slight excess of HCl gas for neutralizing the amine if possible. Using
the gas has an advantage in the sense that the amine Hcl will most likely
crystallize out and not have any appreciable solubility this may not be the
case if you use conc HCl (atleast this has been my experience). Filter the
salt and you should have butanol that is practically neutral in pH. if not
you can neutralize the slight excess of Hcl using ammonia/or bicarb and
distill the butanol.

if your amine Hcl does not crystallize out from butanol then you should try
isopropanol(this has been used for crystallizing small amines the size of
ephedrine) or MTBE. Let me know if this helps.
regards
ravi

-----Original Message-----
From: everybody-bounces$##$orglist.net
[mailto:everybody-bounces$##$orglist.net]On Behalf Of
everybody-request$##$orglist.net
Sent: Wednesday, November 16, 2005 12:19 PM
To: everybody$##$orglist.net
Subject: Everybody Digest, Vol 14, Issue 9


Send Everybody mailing list submissions to
        everybody$##$orglist.net

To subscribe or unsubscribe via the World Wide Web, visit
        http://two.pairlist.net/mailman/listinfo/everybody
or, via email, send a message with subject or body 'help' to
        everybody-request$##$orglist.net

You can reach the person managing the list at
        everybody-owner$##$orglist.net

When replying, please edit your Subject line so it is more specific
than "Re: Contents of Everybody digest..."


Today's Topics:

   1. Neutralization (Kamal)


----------------------------------------------------------------------

Message: 1
Date: Wed, 16 Nov 2005 19:21:06 +0530
From: "Kamal" <mailbox$##$invalid>
Subject: ORGLIST: Neutralization
To: <everybody$##$orglist.net>
Message-ID: <001901c5eab4$cb5b2c50$35dcfea9$##$kamal>
Content-Type: text/plain; charset="iso-8859-1"

Hello Friends !

I have some work-up problem in my solvent media.

I made one Amine HCl in n-Butanol media by acidifying the Amine dissolved in
n-Butanol with hydrochloric acid. Due to this acidification, the butanol
remains acidic & distills also as acidic when I concentrate it to get the
Hydrochloride salt.

Here, my problem is I can not distill this acidic n-BA in my plant as I have
only the SS reactor which can not suffer the acidic vapor or solvent.

I tried adding NaHCO3 to this and made around 5-6 pH, but even at this
slight acidic stage, some hydrochloride salt breaks out to the Amine !

Can anyone pls suggest me something that how I can neutralize this
n-Butanol+Amine HCl mixture so that my hydrochloride salt remains protected
& solvent gets neutralized !

Pls suggest at earliest !





Thanking you in advance,

Kamal






------------------------------

_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message:
unsubscribe your_orglist_password your_address

End of Everybody Digest, Vol 14, Issue 9
****************************************

_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address



Date view Thread view Subject view Author view Attachment view

This archive was generated by hypermail 2.1.4 : Thu Feb 18 2010 - 16:58:10 EST