Re: ORGLIST: Question

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From: ohad ilovich (ilovich$##$pob.huji.ac.il)
Date: Tue Nov 15 2005 - 08:38:14 EST



This is another catalytic hydrogenation method.
it works with a wide variety of benzyls N-benzyl, O-benzyl,
benzyloxycarbonyls and so forth. it's easy and quick and the only problem
might be the price of Pd(OH)2/C
we used it to debenzylate an O-benzyl on a steroid which was resistant to
hydrogentation in the presence of Pd/C

Good Luck
Ohad

----- Original Message -----
From: "Ilya Avrutov" <IAvrutov$##$dalton.com>
To: "alessandro.sala1978" <alessandro.sala1978$##$libero.it>; "everybody"
<everybody$##$orglist.net>
Sent: Monday, November 14, 2005 3:52 PM
Subject: RE: ORGLIST: Question



Catalytic hydrogenation is the classic method (lot of references, here
are just two of them: Chem. Ber. 94, 2442, 1961; JACS, 85, 3719, 1963).
Another method - Na/liquid NH3 (JACS 80, 6083, 1958).

Best,
Ilya


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-----Original Message-----
From: everybody-bounces$##$orglist.net
[mailto:everybody-bounces$##$orglist.net] On Behalf Of alessandro.sala1978
Sent: Friday, November 11, 2005 2:31 AM
To: everybody
Subject: ORGLIST: Question

Hi,
I need some efficient metod for N-debenzylation best regards

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