ORGLIST: N-alkylation

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From: madhav balakrishna mallia (madhavmallia$##$rediffmail.com)
Date: Sat Oct 22 2005 - 13:47:46 EDT

hello i need some suggestions regarding N-alkylation. the substrate is diethylene triamine where both the primary amine groups are protected with phthalimide. i want to N-alkylate the remaining secandary amine with 1,2 dibromoethane i did the reaction using anhy potassium carbonate in acetonitrile. but the reaction is not proceeding. do anyone has an idea, why it is not going and is there a reagent which can drive this reaction without affecting the protective phthalimide group? thanking u in advance Madhava B Mallia Scientific Officer D BHABHA ATOMIC RESEARCH CENTRE Mumbai


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