Re: ORGLIST: Amide coupling under neutral condition

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From: Eugen Leitl (eugen$##$leitl.org)
Date: Wed Jul 27 2005 - 09:09:13 EDT

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On Wed, Jul 27, 2005 at 04:38:58AM +0000, Yuehui Zhou wrote:
> <html><div style='background-color:'><DIV class=RTE>
> A solid base as acid scavenger may work for your case. You need very good stirring or even microwave.
> Y Zhou >From: Shenliang Wang <shenliangwang$##$yahoo.com.cn> >To: everybody$##$orglist.net >Subject: ORGLIST: Amide coupling under neutral condition >Date: Wed, 27 Jul 2005 08:56:33 +0800 (CST) > >Hi all, > >I am doing an amide couping reaction, which couple a >primary amine with an alkyl-chain carboxylic acid. >However, the other part on my acid is not stable at >basic condition, which means I cannot use DIPEA or TEA >as a base, so I cannot use HATU or HBTU or PyBOP, etc. >At the same time, DIC react with this part on the >acid, so I cannot use DIC, DCC, or EDC either. > >So, is there any method for me to coupling this >annoying acid with a primary amine? > >Thanks a
> lot. >Shenliang > > > > > > >___________________________________________________________ >????????G????????????????????????????????????? >http://cn.mail.yahoo.com/?id=77071>> >_______________________________________________ >ORGLIST - Organic Chemistry Mailing List >Website / Archive / FAQ: http://www.orglist.net>>To post a message (TO EVERYBODY) send to everybody$##$orglist.net >To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address >List coordinator: Joao Aires de Sousa (coordinator$##$orglist.net) </DIV></div></html>
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Next message: Jisha C P: "ORGLIST: PMMA ionization potential"
Previous message: Yuehui Zhou: "RE: ORGLIST: Amide coupling under neutral condition"
In reply to: Yuehui Zhou: "RE: ORGLIST: Amide coupling under neutral condition"

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