From: Shenliang Wang (shenliangwang$##$yahoo.com.cn)
Date: Tue Jul 26 2005 - 20:56:33 EDT
I am doing an amide couping reaction, which couple a
primary amine with an alkyl-chain carboxylic acid.
However, the other part on my acid is not stable at
basic condition, which means I cannot use DIPEA or TEA
as a base, so I cannot use HATU or HBTU or PyBOP, etc.
At the same time, DIC react with this part on the
acid, so I cannot use DIC, DCC, or EDC either.
So, is there any method for me to coupling this
annoying acid with a primary amine?
Thanks a lot.
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address
List coordinator: Joao Aires de Sousa (coordinator$##$orglist.net)
This archive was generated by hypermail 2.1.4 : Thu Feb 18 2010 - 16:58:09 EST