From: Maringanti Krishna (maringanti9$##$yahoo.com)
Date: Mon Apr 04 2005 - 02:12:12 EDT
Hi!
Can anyone suggest a good alternative for
TFFH (Fluoro-N,N,N’,N’-tetramethylformamidinium hexafluorophosphate, 97%
CAS Number: 164298-23-1) in amide coupling?
No! EDC/HOBt or HOAt or HATU or pentafluorophenol or mixed anhydride methods dont work in either dichloromethane or THF or in DMF either at rt/reflux/microwave irradiation conditions.
Thanks in advance
Krishna
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