From: mailbox (mailbox$##$prolificint.com)
Date: Sun Mar 06 2005 - 00:41:23 EST
Hello Friends !
I'm trying a lot to perform a reaction of making an aliphatic Isocyanate from its Amine or its Hydrochloride salt. But unfortunately not being succeeded. Using molar ratio as Amine/Amine HCl : Triphosgene : TEA/DIPEA as 1 : 0.4 : 2.0 in toluene & maintaining temperature at reflux & in another experiments the temperature at 70 deg C. The time of reaction I tried from 2 hours to 8 hours. But after the reaction, the TLC & the GC report still shows a large amount of Amine/Amine HCl unconverted. Only 20-25% of Amine is being converted to the Isocyanate.
Can anyone pls give me some advice or some experimental data to complete this reaction ?
Thanking you all in advance,
Kamal Morendha
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