Re: ORGLIST: Mild hydrolysis of Semicarbazide

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From: Jacob Zabicky (zabicky$##$
Date: Tue Feb 22 2005 - 09:05:30 EST

Hello Gunter,

Perhaps a phenolic acid such as p-hydroxybenzoic acid or
p-hydroxybenzenesulfonic acid, forming an inclusion compound with a
cyclodextrine, will provide the mild catalysis you are looking for.
Some references about these inclusion compounds are:

Y. Sueishi and T. Miyakawa, J. Phys. Org. Chem., 12, 541 (1999).
D. Landy, S. Fourmentin, M. Salome and G. Surpateanu, J. Incl. Phenom. =

Macrocycl. Chem., 38, 187 (2000).
B. Mayer, G. Marconi, C. Klein, G. Kohler and P. Wolschann, J. Incl.
Phenom. Mol. Recognition Chem., 29, 79 (1997).
S. H. Kim, M. S. Won and Y. B. Shim, Bull. Korean Chem. Soc., 17, 342
F. Garc ža S anchez, A. Navas D žaz, J. Lovillo and L. S. Feria, =
Chim. Acta, 328,73 (1996).

Please let us know if the thing worked as desired.

Good luck,


Prof. Jacob Zabicky
Institutes for Applied Researcfh
Ben-Gurion University of the Negev
P. O. Box 653
Beer-Sheva, 84105
Tel. +972-8-6461271
Fax. +972-8-6472969
Private: P. O. Box 12366
Beer-Sheva, 84863
Tel. +972-8-6496792

On Feb 21, 2005, at 16:28, Gunter Kuhnle wrote:

> Hallo!
> I try to immobilize a hydrazine with an isocyanate on beads, and I'm =

> looking for a mild method to hydrolyse the semicarbazide after
> purification; initially, I thought urease may be a possibility, but
> the beads are made of polystyrene which does not swell in water [and =

> I'm not sure whether the isocyanate will be accessible to the enzyme].
> Do you have any idea what could be done?
> Thank you!
> Best wishes,
> Gunter
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