From: Richard Prankerd (richard.prankerd$##$vcp.monash.edu)
Date: Tue Feb 17 2004 - 16:38:10 EST
I fully endorse all suggestions made by Jon Kremsky regarding the use of
lyophilization to remove ammonium ions (in the presence of acetate)
Richard
Richard J. Prankerd, PhD
Senior Lecturer
Victorian College of Pharmacy, Monash University
381 Royal Pde., Parkville VIC 3052
Phone: INT+613-9903-9003
Phax: INT+613-9903-9583
Drugs need to be designed with delivery components in mind - Takeru Higuchi
----- Original Message -----
From: "Jon Kremsky" <jkremsky$##$primeorg.com>
To: <nickclark$##$infinito.it>; <everybody$##$orglist.net>
Sent: Wednesday, February 18, 2004 12:55 AM
Subject: RE: ORGLIST:Lyophilisation to remove Ammonium
> Nick: Lyophilization will work, but will probably require several
> iterations. Bring the pH to near neutrality with some acetic acid. That
> gives ammonium acetate, which is a fugitive salt. After a few
> lyophilizations, the acetic acid and ammonia ought to be gone.
>
> Jon Kremsky
>
> -----Original Message-----
> From: everybody-admin$##$orglist.net [mailto:everybody-admin$##$orglist.net]On
> Behalf Of nickclark$##$infinito.it
> Sent: Monday, February 16, 2004 9:33 AM
> To: everybody$##$orglist.net
> Subject: ORGLIST:Lyophilisation to remove Ammonium
>
>
> I am trying to remove water and ammonium from a
> saline-like biological sample.
>
> Is lyophilisation likely to be an appropriate way of doing
> this? Loss of other volatiles is not a problem, though I
> would like to retain glucose.
>
> Any suggestions would be most welcome.
>
> Yours faithfully
>
> Nick Clark
>
> St George's Hospital Medical School
> United Kingdom
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