RE: ORGLIST:methylation problem

Date view Thread view Subject view Author view Attachment view

From: Yuehui Zhou (yuehuizhou$##$hotmail.com)
Date: Thu Dec 11 2003 - 15:53:06 EST

Dear Srinivas,

I think the resultant compound does make sense since I anion is better nucleophile than Br anion. It's a simple halide nucleophilic substitution. To keep the Br there you may try other methylating reagent such as dimethylsulfate or methylsulfonate, if the iodide anion is not essential for your compound.

Y. Zhou 

>From: srinivas reddy
>To: everybody@orglist.net
>Subject: ORGLIST:methylation problem
>Date: Wed, 10 Dec 2003 10:59:39 -0800 (PST)
>
>Dear all,
>
>I had a problem of methylating (using methyl Iodide)my
>bromonated caroblines(indoloquinolines). these were
>substituted by the iodine while i did the methylation
>reaction,the methylation did work but the  the mass
>spec shows the mass of a iododerivative, can anybody
>explain what ha happend,the reasons and literatute
>evidence about this reaction.
>
>regards
>
>Srinivas
>
>=====
>G.S.Reddy
>
>
>__________________________________
>Do you Yahoo!?
>Protect your identity with Yahoo! Mail AddressGuard
>http://antispam.yahoo.com/whatsnewfree
><< methylation.doc >>

Shop online for kids’ toys by age group, price range, and toy category at MSN Shopping. No waiting for a clerk to help you! _______________________________________________ ORGLIST - Organic Chemistry Mailing List Website / Archive / FAQ: http://www.orglist.net To post a message (TO EVERYBODY) send to everybody@orglist.net To unsubscribe, send to everybody-request@orglist.net the message: unsubscribe your_orglist_password your_address List coordinator: Joao Aires de Sousa (coordinator@orglist.net)
Date view Thread view Subject view Author view Attachment view

This archive was generated by hypermail 2.1.4 : Wed Jan 14 2004 - 08:37:01 EST