From: Martijn Slagt (m.slagt$##$syncom.nl)
Date: Thu Dec 11 2003 - 07:03:21 EST
Dear Srinivas,
Your quinoline derivative obviously suffered from nucleophillic
aromatic substitution. This type of reactivity is known for pyridines
and benzene derivatives functionalized with (multiple) NO2 or cyano
groups. The best way to solve your problem would be to use a methylating
agent with a non-nucleophillic leaving group such as dimethylsulfate.
good luck!
Martijn
Dr. Martijn Q. Slagt
Research Chemist
SYNCOM B.V.
Kadijk 3
9747 AT Groningen
tel. +31 (0)50 5757386
fax +31 (0)50 5757399
http://www.syncom.nl
>>> srinivas reddy <gounisrinivas$##$yahoo.com> 10-12-2003 19:59:39 >>>
Dear all,
I had a problem of methylating (using methyl Iodide)my
bromonated caroblines(indoloquinolines). these were
substituted by the iodine while i did the methylation
reaction,the methylation did work but the the mass
spec shows the mass of a iododerivative, can anybody
explain what ha happend,the reasons and literatute
evidence about this reaction.
regards
Srinivas
=====
G.S.Reddy
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