Re: ORGLIST:TLC of Nitriles

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From: Sharon Stone-Elander (sharon.stone$##$ks.se)
Date: Mon Nov 03 2003 - 10:35:02 EST

Hello Mark,
Fluorbenzonitrile is volatile. When we've labelled it with fluorine-18, eluted on a TLC plate and immediately scanned for product with a radioTLC scanner, only the nonvolatile fluoride was detected. However, the fluorobenzonitrile had actually been formed in >80% conversions, as was shown by SPE procedures followed by radio-HPLC characterization of the eluent. The nitrile apparently completely disappears from the TLC plate during elution and subsequent drying /scanning.

Chances are this is the reason you've been unable to visualize the fluorobenzonitrile.

with greetings,
Sharon Stone-Elander

At 00.00 -0500 03-10-31, researchstuff$##$bellsouth.net wrote:
> Hello everyone,
>
> Does anyone know of a TLC stain to visualize nitriles? I have tried vanillin, KMnO4, Iodine, and PMA, and neither worked. The reagent that I need to monitor in a reaction is fluorobenzonitrile.
>
> Thanks for any help.
>
>Mark
> 

-- 
++++++++++++++++++++++++++++++++++++++++
Sharon Stone-Elander, Ph.D.
Professor of Medicinal Radiochemistry, Karolinska Institute
Department of Clinical Neuroscience, Positron Emission Tomography
Mailing address: 
Karolinska Pharmacy, Karolinska Hospital, S-171 76 Stockholm, Sweden
Email: sharon.stone$##$ks.se;   Tel. +46 8 5177 53 31;   Fax. +46 8 30 73 46
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