ORGLIST:coupling indoles with acid chlorides

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From: Witek Mozga (mozga$##$trimen.pl)
Date: Tue Oct 14 2003 - 02:28:56 EDT

Hi,

I need a procedure to react an indole with a carbonyl chloride to
give 3-substituted indole. I know that this can be done using
Grignard reagent to abstract hydrogen to activate indole ring or just
by a simple reaction of indole with a chloride. I want to avoid
Grignard reagent and thus I found such references:
J. Med. Chem. 33; 2; 1990; 543-552
J. Med. Chem. 33; 2; 1990; 755-758
I have the journal in my library but the particular issue is missing.
Has snybody read it or know similar procedure?

Please advise

Witek Mozga
TriMen Chemicals
http://www.trimen.pl/

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