Re: ORGLIST:Cl-TMS/MeOH formation of esters

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From: Richard Bychowski (noEmail$##$given.for.spam)
Date: Wed Sep 17 2003 - 15:45:02 EDT

I haven't used this procedure. What happens is formation of dry HCl in
methanol, followed by a Fischer esterification. The TMS methyl ether
byproduct is probably volatile, which is nice. Thionyl chloride will
also form dry HCl in methanol.

Richard Bychowski

On Wednesday, September 17, 2003, at 04:27 AM, Jacobo Cruces wrote:

> Hi,
>
> Can anybody give me a good paper or a first hand experience on the
> preparation of methyl esters by using trimethylsilyl chloride and
> methanol? Comments on mechanism would also be appreciated...
>
>
>
> Visit us at CPhI in Frankfurt next October 27-28-29, Stand X942 - Hall
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