From: Michael Kilkelly (Michael.Kilkelly$##$schwarzpharma.ie)
Date: Thu Jun 19 2003 - 07:11:56 EDT
I have come across the reaction of dichloromethane with primary amines to give cyclic compounds of the type (RNH2)3 . On a laboratory scale the atmospheric distillation of a dichloromethane solution of this primary amine was fine but on the extended 2000L scale, the distillation was quite slow and a significant amount of the cyclic compound was formed (50-70%).
I would recommend to avoid using methylene chloride in thefirst place.
_______________________________________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net
To post a message (TO EVERYBODY) send to everybody$##$orglist.net
To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address
List coordinator: Joao Aires de Sousa (coordinator$##$orglist.net)
This archive was generated by hypermail 2.1.4 : Fri Sep 19 2003 - 12:17:26 EDT