From: Jacobo Cruces (jacobo.cruces$##$galchimia.com)
Date: Wed Jun 18 2003 - 14:44:57 EDT
Dear all,
Thanks to the people who answered my message. Some solutions were
suggested, but due to the type of reaction being carried out (SN2) and the
moieties present in the product, most of them can not be used. The methods
suggested were:
1. Removal using rotavapor/high vacuum. This is the method we were just
trying, but due to the high quantities of hydrazine being used it takes a
long time. We finally used a combination of this method and extraction with
organic solvent (ethyl acetate, though the product is also water soluble
and yields are reduced).
2. Formation of the hydrazine oxalate; once again, due to the nature of the
product cannot be used, but I think this method (Journal of the American
Society, vol. 32, pages 577-588) deserves a special attention.
3. Use of IPA as solvent, followed by removal in high vacuum. Incompatible
with our product.
4. Reaction of excess formaldehyde to give a byproduct from the hydrazine
which can be eliminated. Incompatible with our product.
5. Use of a solid phase resin compatible with the product. Since the
reaction was carried out at very big scale, not possible.
Hope this helps to other people.
Best regards,
Dr. Jacobo Cruces
Research Manager
GalChimia, S.L.
Cebreiro, s/n O Pino
15823 A Coruņa
SPAIN
Phone: +34 981 814 506
Fax: +34 981 814 507
Home: www.galchimia.com
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