Re: ORGLIST:Deactivation of LAH

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From: Prof. Jacob Zabicky (zabicky$##$bgumail.bgu.ac.il)
Date: Sun Apr 20 2003 - 08:19:54 EDT

Hello,

This probably depends on what has been reduced and what one wants to do
afterwards. Possibly the easiest procedure would be adding some excess
acetone, followed by an aqueous acidic treatment in the final workup.

All the best,

Jacob
----- Original Message -----
From: "Merlin" <medchem$##$comcast.net>
To: "Discussion Groups" <medchem$##$comcast.net>
Sent: Tuesday, April 15, 2003 1:45 PM
Subject: ORGLIST:Deactivation of LAH

> Greetings!
>
> Currently We utilize LAH in our reductions; no problem. However my
question
> does concern the deactivation of residual LAH which is present in
glassware
> both after initial addition (funnels, cannulas, etc.) and after final
> hydrolysis (flasks).
>
> When We use LAH as a 1M solution in THF, EtOAc is used at room temp to
> deactivate with no difficulty. We are currently investigating LAH as a
3.5M
> solution in Toluene/THF. Yet when I had attempted to deactivate residual
LAH
> in the addition funnel, quite a bit of hydrolysis/heat was observed.
>
> Question: has anyone used LAH in Toluene/THF (3.5M)? If so, how was the
> residual LAH deactivated?
>
> Thank you in advance.
>
> Sincerely,
> --
> George D. 'Merlin' McCallion
> Associate Research Scientist
> Chemical Development
> Sanofi-Synthelabo Research
> 25 Great Valley Parkway
> Malvern, PA 19355
> United States
>
> Office: 610.889.6294
> Fax: 610.889.6367
> E: George.McCallion$##$sanofi-synthelabo.com
>
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