ORGLIST:Deactivation of LAH

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From: Merlin (medchem$##$comcast.net)
Date: Tue Apr 15 2003 - 07:45:24 EDT

Greetings!

Currently We utilize LAH in our reductions; no problem. However my question
does concern the deactivation of residual LAH which is present in glassware
both after initial addition (funnels, cannulas, etc.) and after final
hydrolysis (flasks).

When We use LAH as a 1M solution in THF, EtOAc is used at room temp to
deactivate with no difficulty. We are currently investigating LAH as a 3.5M
solution in Toluene/THF. Yet when I had attempted to deactivate residual LAH
in the addition funnel, quite a bit of hydrolysis/heat was observed.

Question: has anyone used LAH in Toluene/THF (3.5M)? If so, how was the
residual LAH deactivated?

Thank you in advance.

Sincerely, 

--
George D. 'Merlin' McCallion
Associate Research Scientist
Chemical Development
Sanofi-Synthelabo Research
25 Great Valley Parkway
Malvern, PA 19355
United States

Office: 610.889.6294
Fax: 610.889.6367
E: George.McCallion$##$sanofi-synthelabo.com

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