From: Barnes, Roger (BarnesR$##$UKOrg.Huntingdon.com)
Date: Tue Mar 04 2003 - 03:36:39 EST
Thanks to those who replied to my previous query re selective protection of
alcohol/phenol. Here is another similar problem - 2 actually!
I am trying to open an epoxide to give the least substituted alcohol in the
presence of a carbamate. Various reagents are reported to give the right
product - e.g. borane/THF - with epoxides carrying a terminal CH2 group -
does anybody have experience with a tri-substituted epoxide? And will the
carbamate group be reduced by these conditions? - I can find little
literature on carbamate reduction.
Hope this will stimulate some interest - and help me with my synthesis!
HUNTINGDON LIFE.SCIENCES LIMITED
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