ORGLIST:BBr3 deactivation

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From: Merlin (medchem$##$att.net)
Date: Tue Nov 05 2002 - 21:48:32 EST

Dear colleagues:

Currently I am using BBr3 for demethylation of a aryl methyl ether to a
phenol.

My questions is: what are some ideas on deactivating the excess BBr3/HBr in
the reaction mixture?

This is to ensure that no remaining HBr can brominate the aromatic ring
system.

I have used MeOH followed by sat. NaHCO3 to reach a pH of 7-9; unfortunately
this yielded a very messy emulsion.

Thank you in advance.

Cheers! 

--
George D. 'Merlin' McCallion
Associate Research Scientist
Chemical Development
Sanofi-Synthelabo Research
25 Great Valley Parkway
Malvern, PA 19355
United States

Office: 610.889.6294
Fax: 610.889.6367
E: George.McCallion$##$sanofi-synthelabo.com

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