ORGLIST:Reduction of 1H-2-pyridones

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From: Merlin (medchem$##$worldnet.att.net)
Date: Thu Sep 05 2002 - 22:10:27 EDT

Dear colleagues:

Has anyone performed a reduction of a 1H-2-pyridone system to a tetrahydro
pyridine system? Currently I use a 10 molar excess of LAH (1M in THF), then
after workup, take the crude into MeOH and use a 10-fold excess of NaBH4.

I monitor by HPLC, but seem to get a 50:50 mix of alcohol and reduced
material (after workup from LAH).

Any assistance would be helpful.

Thank you in advance. 

--
George D. 'Merlin' McCallion
Associate Research Scientist
Chemical Development
Sanofi-Synthelabo Research
25 Great Valley Parkway
Malvern, PA 19355
United States

Office: 610.889.6294
Fax: 610.889.6367
E: George.McCallion$##$sanofi-synthelabo.com

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