From: Sharon Stone-Elander (sharon.stone$##$ks.se)
Date: Mon May 06 2002 - 02:49:23 EDT
Hi!
We used BCl3 to perform a Me-O-Ph cleavage previously and were not
impressed, though it was the best of the reagents we tested at the
time.
We recently revisted the problem and have found that CH3SO3H, with
microwave or conventional heating is both faster and, with the
compounds we tested, appears to be cleaner.
The paper is available on line in J. Labelled Cpd Radiopharm. The reference is
Fredriksson A. and Stone-Elander S. (2002) Rapid microwave-assisted
cleavage of methyl phenyl ethers: New method for synthesizing
desmethyl precursors and for removing protecting groups. J- Labelled
Cpd. Radiopharm. 45, 529-538.
With greetings,
Sharon Stone-Elander
At 02.44 -0400 02-05-03, Merlin wrote:
>Currently I am using BCl3 to perform a Me-O cleavage.
>
>Has anyone used this rgt?
>
>Thank you in advance.
>
>Cheers!
>--
>George D. 'Merlin' McCallion
>Associate Research Scientist
>Chemical Development
>Sanofi-Synthelabo Research
>25 Great Valley Parkway
>Malvern, PA 19355
>United States
>
>Office: 610.889.6294
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>
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-- ++++++++++++++++++++++++++++++++++++++++ Sharon Stone-Elander, Ph.D. Professor of Medicinal Radiochemistry, Karolinska Institute Department of Clinical Neuroscience, Positron Emission Tomography Mailing address: Karolinska Pharmacy, Karolinska Hospital, S-171 76 Stockholm, Sweden Email: sharon.stone$##$ks.se; Tel. +46 8 5177 53 31; Fax. +46 8 30 73 46 ++++++++++++++++++++++++++++++++++++++++__________________
ORGLIST - Organic Chemistry Mailing List Website / Archive / FAQ: http://www.orglist.net/ List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)
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