Re: ORGLIST: Hydrogenation of benzylcaronyloxy(CBZ) protection group

From: Jonas Nilsson (jonni$##$ifm.liu.se)
Date: Wed Sep 05 2001 - 03:55:24 EDT

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The only source of sulfur that was used was benzylsulfonyl chloride. This
however was 3 steps earlier in the synthesis and 2 column chromatography
purifications was made inbetween.

About the acidity. The compound contains no acidic protons. The Z-protect=
ed
amidine is basic, and before hydrogenation, column chromatography was
performed with ammonia in the mobile phase. This means that the compound
should have been slight to moderate basic.

Will this help you helping me?
Thank you for your time.

Best regards
/jN
__________________
Jonas Nilsson
IFM Kemi
Linköpings Universitet
013-285690

----- Original Message -----
From: "Ilfir Ramazanov" <chemelf$##$gmx.net>
To: "Jonas Nilsson" <jonni$##$ifm.liu.se>
Sent: Wednesday, September 05, 2001 7:11 AM
Subject: Re: ORGLIST: Hydrogenation of benzylcaronyloxy(CBZ) protection
group


|
| Hello Jonas,
|
| What about acidity of the compound? Is there a trace of sulfur from
| previous procedure?
|
| Ilfir
|
|
|

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