ORGLIST: tercbutylamide from a methyl ester

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From: Marino Tadeu Fabi (mtadeu$##$mpc.com.br)
Date: Tue Oct 17 2000 - 02:42:36 EDT

CAn someone help me with a good procedure for transforming an methyester of
a substituted l-serine into a tert butyl amide of the same substituted
serine without racemizing the S center?
It's a procedure that has to be implanted in large scale!!
this is very important to me....
I know I can hydrolyze the ester and afterword essay to treat for instants
with tercbutylamine and oxalylchloride, or dimetilamiopiridine...etc...but
I'm afraid of racemizing!!
my first interest is the direct transformation of the ester into the
tertbutylamide....is this possible? how?
thank you very much
Marino

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