ORGLIST: hydrolysis of mesylated alcohol to give the inversed configuration?

From: Yantao Chen (yanch$##$ifm.liu.se)
Date: Tue Sep 12 2000 - 11:04:45 EDT

• Next message: Bohlen, Jost T.: "AW: ORGLIST: hydrolysis of mesylated alcohol to give the inverse d configuration?"
• Previous message: Fattori Daniela: "RE: ORGLIST: Thioester activation"

Dear Members:

Mitsunobu Inversion, which is very useful in some cases, may only give the elimination product. From Beilstein database, I found one method to get the inversed stereochemistry through hydrolysis of mesylated starting material in TsOH/ H2O mixture. However, in the reference, there is no experimental details. Does anyone have some related experience on hydrolysis or just give your comments on this methodology?

Thank you very much.

Sincerely,

Yantao Chen
yanch$##$ifm.liu.se

__________________

ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net/
List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)

• Next message: Bohlen, Jost T.: "AW: ORGLIST: hydrolysis of mesylated alcohol to give the inverse d configuration?"
• Previous message: Fattori Daniela: "RE: ORGLIST: Thioester activation"

This archive was generated by hypermail 2.1.4 : Fri Sep 19 2003 - 12:15:35 EDT