From: Eugene Leitl (eugene.leitl$##$lrz.uni-muenchen.de)
Date: Tue Jul 25 2000 - 18:19:47 EDT
Hi,
I'm trying to make about 30 g of 3-chloroprocainamide (declopramide),
which (I presume) looks thusly:
The only literature ref I've found (not yet in my hands) so far is
Hua J, Pero RW 1999. Pharmacokinetics and central nervous system
toxicity of declopramide (3-chloroprocainamide) in rats and mice.
Anti Cancer Drugs, 10:79-8
In case anyone knows a handy literature ref for synthesis of either
abovementioned, or metaclopramide (very much the same thing, only with
an extra methoxy group) I would very much appreciate that.
I was thinking about making 3-chloro, 4-amino benzoyl chloride with a
protected amino group (which protective group would you suggest? I
obviously can't use an amide, since it's present in the target
molecule), and let it react with assymetrical N,N-diethylethyldiamine
(which I presume is commercially obtainable), in pyridine or
triethylamine.
Do you see any failures with such a scheme? Any alternative
suggestions?
Thank you very much.
-- Eugene
__________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net/
List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)
This archive was generated by hypermail 2.1.4 : Fri Sep 19 2003 - 12:15:35 EDT