Re: ORGLIST: microscale organic chemistry

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From: Sharon Stone-Elander (sharon.stone$##$neuro.ks.se)
Date: Thu Jul 06 2000 - 09:48:19 EDT

Hi Chris,
Thank you very much. I agree that the reviewer may not be working with
areas (as mine and yours) in which one or the other of the starting
materials might be particularly precious. Although we briefly mentioned
this aspect, it seems that it should be more strongly emphasized.
Thanks again,
Sharon

>We always work on a mg scale and do all optimizations on the same scale
>(normally even smaller). This is mostly do to the cost of our
>basic starting material ($1000/g) and the fact that only 3-4 mg of a final
>product are needed for testing. My guess is the reviewer is not familier
>with microscale synthesis and was looking for something to complain about.
>
>Good luck,
>Chris
>
>On Wed, 5 Jul 2000, Sharon Stone-Elander wrote:
>
>> Hello,
>> I'm curious. I just received a criticism from a reviewer about the fact
>> that we had optimized and performed a reaction on the scale of a few
>> milligrams. He/she questioned the relevance, because of possible problems
>> with eventually scaling up the reaction. I always work with micro-scale
>> reactions in my labelling work, but this was not a labelling application.
>> I'm wondering how many of you in other areas of organic chemistry typically
>> optimize and perform reactions on a mg level -either when trying new
>> reactions or preparatively for a series of similar compounds from the same
>> family?
>> Thanks,
>> Sharon
>>
>> ________________________________________________
>> Sharon Stone-Elander, Ph.D.
>> Professor of Medicinal Radiochemistry, Karolinska Institute
>> Department of Clinical Neuroscience, Positron Emission Tomography
>>
>> Mailing address:
>> Karolinska Pharmacy, Karolinska Hospital
>> S-171 76 Stockholm, Sweden
>> Email: sharon.stone$##$neuro.ks.se
>> Tel. +46 8 5177 53 31; Fax. +46 8 30 73 46
>> _______________________________________________
>>
>>
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>>
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>>
>
>__________________
>
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________________________________________________
Sharon Stone-Elander, Ph.D.
Professor of Medicinal Radiochemistry, Karolinska Institute
Department of Clinical Neuroscience, Positron Emission Tomography

Mailing address:
Karolinska Pharmacy, Karolinska Hospital
S-171 76 Stockholm, Sweden
Email: sharon.stone$##$neuro.ks.se
Tel. +46 8 5177 53 31; Fax. +46 8 30 73 46
_______________________________________________

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ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net/
List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)

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