From: Christopher Paul Borella (cborella$##$ic.sunysb.edu)
Date: Wed Jul 05 2000 - 13:35:29 EDT
We always work on a mg scale and do all optimizations on the same scale
(normally even smaller). This is mostly do to the cost of our
basic starting material ($1000/g) and the fact that only 3-4 mg of a final
product are needed for testing. My guess is the reviewer is not familier
with microscale synthesis and was looking for something to complain about.
Good luck,
Chris
On Wed, 5 Jul 2000, Sharon Stone-Elander wrote:
> Hello,
> I'm curious. I just received a criticism from a reviewer about the fact
> that we had optimized and performed a reaction on the scale of a few
> milligrams. He/she questioned the relevance, because of possible problems
> with eventually scaling up the reaction. I always work with micro-scale
> reactions in my labelling work, but this was not a labelling application.
> I'm wondering how many of you in other areas of organic chemistry typically
> optimize and perform reactions on a mg level -either when trying new
> reactions or preparatively for a series of similar compounds from the same
> family?
> Thanks,
> Sharon
>
> ________________________________________________
> Sharon Stone-Elander, Ph.D.
> Professor of Medicinal Radiochemistry, Karolinska Institute
> Department of Clinical Neuroscience, Positron Emission Tomography
>
> Mailing address:
> Karolinska Pharmacy, Karolinska Hospital
> S-171 76 Stockholm, Sweden
> Email: sharon.stone$##$neuro.ks.se
> Tel. +46 8 5177 53 31; Fax. +46 8 30 73 46
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