From: inewington$##$kodak.com
Date: Wed Jul 05 2000 - 12:08:34 EDT
From: Ian Newington
I would not spend a lot of time doing a full optimization on the
micro-scale because your reviewer is correct in that there will inevitably
be problems scaling up to any production scale. A 'rule of thumb' common
among organic chemists says you can double the scale without any problems
but any more will give different results and need re-optimization.
There is a change coming where scale-up could be replaced by 'scale-out' in
some cases. This involves use of microreactors, technology commonly known
as 'lab-on-a-chip'. In this case instead of increasing the scale, you
simply multiply the number of chips - it's analogous to adding memory to
your PC.
Ian Newington
R&D Kodak Ltd
email: inewington$##$kodak.com
---------------------- Forwarded by Ian
Newington/959031/GreatBritain/Europe/EKC on 05/07/2000 17:02
---------------------------
Sharon Stone-Elander <sharon.stone$##$neuro.ks.se> on 05/07/2000 16:47:41
To: Multiple recipients of list orglist <orglist$##$dq.fct.unl.pt>
cc: (bcc: Ian Newington/959031/GreatBritain/Europe/EKC)
Subject: ORGLIST: microscale organic chemistry
Hello,
I'm curious. I just received a criticism from a reviewer about the fact
that we had optimized and performed a reaction on the scale of a few
milligrams. He/she questioned the relevance, because of possible problems
with eventually scaling up the reaction. I always work with micro-scale
reactions in my labelling work, but this was not a labelling application.
I'm wondering how many of you in other areas of organic chemistry typically
optimize and perform reactions on a mg level -either when trying new
reactions or preparatively for a series of similar compounds from the same
family?
Thanks,
Sharon
________________________________________________
Sharon Stone-Elander, Ph.D.
Professor of Medicinal Radiochemistry, Karolinska Institute
Department of Clinical Neuroscience, Positron Emission Tomography
Mailing address:
Karolinska Pharmacy, Karolinska Hospital
S-171 76 Stockholm, Sweden
Email: sharon.stone$##$neuro.ks.se
Tel. +46 8 5177 53 31; Fax. +46 8 30 73 46
_______________________________________________
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