ORGLIST: microscale organic chemistry

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From: Sharon Stone-Elander (sharon.stone$##$neuro.ks.se)
Date: Wed Jul 05 2000 - 11:47:41 EDT

Hello,
I'm curious. I just received a criticism from a reviewer about the fact
that we had optimized and performed a reaction on the scale of a few
milligrams. He/she questioned the relevance, because of possible problems
with eventually scaling up the reaction. I always work with micro-scale
reactions in my labelling work, but this was not a labelling application.
I'm wondering how many of you in other areas of organic chemistry typically
optimize and perform reactions on a mg level -either when trying new
reactions or preparatively for a series of similar compounds from the same
family?
Thanks,
Sharon

________________________________________________
Sharon Stone-Elander, Ph.D.
Professor of Medicinal Radiochemistry, Karolinska Institute
Department of Clinical Neuroscience, Positron Emission Tomography

Mailing address:
Karolinska Pharmacy, Karolinska Hospital
S-171 76 Stockholm, Sweden
Email: sharon.stone$##$neuro.ks.se
Tel. +46 8 5177 53 31; Fax. +46 8 30 73 46
_______________________________________________

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