ORGLIST: Tertbutyl benzoylacetates

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From: Dr. Jose I. Borrell (jibor$##$iqs.url.es)
Date: Fri Jun 30 2000 - 07:59:10 EDT

Dear list members,

We are trying to obtain a series of tertbutyl benzoylacetates by
condensation of the corresponding methyl benzoates (substituted in position
3 or 4) and tertbutyl acetate using LDA as the base.

The reaction, however, is not working properly and large amounts of
tertbutyl acetoacetate are formed. We have not found a literature reference
covering such transformation (most of them use benzoyl chlorides instead of
the benzoate but we can not use them).

Help will be highly appreciated. Particularly a detailed procedure for such
transformation.

Thanks in advance.

============================
Dr. Jose I. Borrell
Institut Quimic de Sarria
Universitat Ramon Llull
Via Augusta 390
08017 Barcelona (Spain)
tel: 34-93.203.89.00 ext 2354
fax: 34-93.205.62.66
e-mail: jibor$##$iqs.url.es
http://www.iqs.url.es
============================

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